science says on the ALS connection
![Twenty-five years ago, Dwight Clark made one of the greatest catches in NFL history. It changed his career, started the San Francisco 49ers dynasty and, for a period of time, ended the Dallas Cowboys' reign as the NFC's top team. Clark a native of Charlotte, N.C., won five Super Bowl rings with the 49ers as a player and front office executive. (Jeff Siner/Charlotte Observer/TNS)](https://www.ajc.com/resizer/KIGH3c6jN-R7yjHljLIcLtl_Uzo=/500x282/cloudfront-us-east-1.images.arcpublishing.com/ajc/BC6KH3MSXZ5ANTCYVET2HHH3AQ.jpg)
Credit: Jeff Siner
The news this week has centered on the tragic plight of Dwight Clark, but at least a dozen other NFL players have suffered from the fatal neurodegenerative disease ALS.
Seven had died from Lou Gehrig’s disease by the time Clark passed away Monday at age 61 — including three members of the 1964 49ers.
The high incidence of amyotrophic lateral sclerosis among the professional football community has led researchers to explore links to the game. In 2012, federal researchers had established that retired pro football players were four times more likely to die from ALS than the general U.S. population, which has five cases per 100,000 people.
The report relied on data from 3,439 ex-players who had been in the NFL at least five seasons from 1959 to 1988. Using death certificates as their basis, researchers also discovered the players had triple the risk of death from brain diseases compared to other people.
Clark suspected football caused his condition. In a March 19, 2017 letter announcing his situation, the popular receiver who is known for “The Catch” urged NFL and players union officials “to continue working together in their efforts to make the game of football safer, especially as it relates to head trauma.”
But ALS remains one of the most complex puzzles for medical researchers. Scientists have yet to find a cause for a disease that first gained national attention 78 years ago through New York Yankees’ star Lou Gehrig.
“We know that a protein that gets released during stress, concussions and neurological damage is implicated as a cause for ALS as well as other neurodegenerative diseases,” Fred Fisher, president and CEO of the ALS Association’s Golden West Chapter, told this news organization last year. “But there are people just like you and me who end up getting the disease for no apparent reason.”
In late 2016, physicians at the Boston University Brain CTE Center announced they had found an ALS connection with the brain disease chronic traumatic encephalopathy, which only can be diagnosed in cadavers.
Ann McKee, the center’s director, also said at the time that 17 brain autopsies performed on football and soccer player thought to have died of ALS showed signs of CTE.
The research is far from conclusive, leading families of athletes struggling with ALS to continue to push for concrete answers.
“I pray for a cure and no more heartache and suffering for those that have been touched by this horrific disease,” Chie Smith, the wife of former Raiders fullback Steve Smith, posted on Facebook on Monday.
Steve Smith, 53, is one of the 13 known former NFL players to suffer from ALS.